pain

Cause emotional anguish or make miserable.

“It pains me to see my children not being taught well in school”

Cause bodily suffering to and make sick or indisposed.

A symptom of some physical hurt or disorder.

“the patient developed severe pain and distension”

Emotional distress; a fundamental feeling that people try to avoid.

“the pain of loneliness”

A somatic sensation of acute discomfort.

“as the intensity increased the sensation changed from tickle to pain”

Something or someone that causes trouble; a source of unhappiness.

A bothersome annoying person.

“that kid is a terrible pain”